Bio Clinical Biostatistics Multiplicity Graphical

About this skill

Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.

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0 potential findings · Scanned 11/4/2026 · Scanner 0.2.1

Content SHA-256: e248437589aeae80bee738ee4a1973d252de912b3c4d88fbf1ceffa5e6339630

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Original listing metadata

Original name

bio-clinical-biostatistics-multiplicity-graphical

Original description

About this listing

Category: Science & research
Reported license: Not specified
Listing language (estimated): English
Review status: Not individually reviewed
Agent compatibility: Atlas installation supports Claude Code, Codex, and Cursor. Skill-specific dependencies and features are checked during setup.